Introduction Of Secretory Diarrhea

Secretory diarrhea means that there is an increase in the active secretion, or there is an inhibition of absorption. The most common cause of this type of diarrhea is a cholera toxin and E.coli those stimulate the secretion of anions, especially chloride ions .Bacterial and viral infections usually included in the etiology of diarrhea  and these pathogens are present in wide diversity which complicates the process of  accurate surveillance and diagnosis, especially in developing countries with little or no access to modern laboratory procedures. The specific disease burden attributable to a particular infectious agent is particularly complex, given the multiplicity of these agents and their serotypes, and its accurate documentation depends largely on laboratory facilities. While, in the long term, access to clean water, better hygiene, adequate nutrition, and improvement of sanitary measures would certainly have the greatest impact on diarrhea diseases, Some other varieties of bacterial pathogens such as Staphylococcus aureus, Clostridium perfringens, Clostridium difficile or Klebsiella spp, as well as by various protozoa including Giardia, Cyclospora and Cryptosporidium spp (e.g. Giardia lambia, Cryptosporidium parvum) and Entamoeba histolytica are also included in etiology of diarrhea diseases. The leading cause of diarrhea disease in young children throughout the world is rotavirus.

Significance of the results

A significant difference was identified, concluding that frequency of diarrhea and associated symptoms were significantly reduced when treated with Dirasif. The data offered support to the experimental hypothesis and therefore null hypothesis was rejected.

Epidemiology

Diarrhea diseases are one of the leading causes of childhood morbidity and mortality in developing countries. An estimated 1,000 million episodes occur each year in children under 5 years of age. Diarrhea causes an estimated 5 million deaths in children fewer than 5 years of age per year. About 80% of these deaths occur in children in the first 2 years of life. Approximately one third of deaths among children fewer than five are caused by diarrhea . In the year 2000, diarrhea diseases claimed an estimated 1.4 to 2.5 million lives; they are among the leading causes of death in children in developing countries. Both the incidence and the risk of mortality from diarrhea diseases are greatest among children younger than 1 year of age, and thereafter rates decline incrementally. Other direct consequences of diarrhea in children include malnutrition, diminished growth, and impaired cognitive development in resource-limited countries.

Treatment assignment and Follow-up

One hundred patients consented to participate in the study. Pretreatment clinical and laboratory parameters (stool D/R) for the treatment groups were noted. The two treatment groups were comparable in efficacy results and side effects of the medicine administered. All subjects were clinically studied and completed the assigned therapy during the period 2007 to 2009.

Loose motion

The loose motion before treatment there was no difference between test and control group at base line and after treatment in test and control group showed, test group (Dirasif) has 90% improvement as compared to control (Furoxone) 74% improvement. After applying the test of significance there was significant difference between these two drugs with Chi-Square Test was applied and p-value was calculated as 0.03 .

Abdominal pain

Dirasif was prescribed to 7 patients with complaint of abdominal pain. After the treatment with herbal drug

Dirasif. All patients showed complete improvement.

Furoxone was prescribed to 5 patients with complaint of abdominal pain. After the treatment with allopathic medicine Furoxone 1 out of 5 showed complete improvement and 4 patients showed no improvement.

The abdominal pain before treatment there was little difference between test and control group as shown in table. and after treatment in test and control group showed, test group (Dirasif) has 100% improvement and control (Furoxone)  showed 20% improvement. After applying the test of significance there was significant difference between these two drugs with Chi-Square Test was applied and p-value was calculated as 0.0036

Evidence Based Medicine

The books on traditional medicine are replete with the usage of medical treatment and
comprehensive literatures on the medical benefits. There are descriptive naration in its
very length and approach to treat ailments. However the documentations. in, the old
treatments of medical etiology are without any valid evidence based on clinical
assessment as evidence based medicine. This shortage of clinical based dosage form
design of traditional medicine has created a negative impact. Although it is a possibility
that traditional medicine used in ancient time till to date may have repeatedly been used
to cure different ailments. Though it may have pronounced type of pharmacological
effect and may be involved to bring about the mode of treatment. But in the absence of
any valid scientific documents the traditional medicine will not be accepted and should
riot be accepted as the genuine materia medica with specific medical effects. It is in the
best of traditional medicine to carryout extreme investigation and provides sufficient
evidence of the traditional medicine to be evidence-based medicine. All this is not
required as an image building process but definite grounds of the medical rules, are to be
followed that will provide traditional medicine a permanent status about its efficacy to be
prescribed in diseases.                                      ..•      '
 

Diagnosis

Diagnosis is one of the most advance area in the medical circle and investigation bring
about exactly to pin point in a patient that he is suffering from the diseases. In the olden
days, the physician use to bring about a clinical investigation based on the sign and
symptom of the diseases. That's why shotgun therapy was the dominant factor and
physician use to rely more on their clinical judgment. But with the advent of
technological explosion the diagnosis seems to be progressively under coming for
chemical and physical analysis and the method of diagnoses is going to expand in leaps
and bounds in the distant not so far.

Conclusion

The scientific and technological advancement of modem medicine has ruled over the last